- Anti-human PD1 mAb
- Product Number : CB-1120500
- Size : 500 µg
- Store at : see datasheet
- Sterile : Yes
- HS-Code : 29371900
- Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1,
- A type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators.
- PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes.
- PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family.
- PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ.
- PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines.
- PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
- In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.
- In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.
- Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
- Storage conditions and stability
+ Lyophilized PD-1 is stable at 2 – 8 °C for 24 months from production date.
+ The lyophilized PD-1 should be reconstituted in sterile distilled water to your desired concentration.
+ Should be stored in working aliquots at -20°C when reconstituted
